Opioid activity is because of both lower affinity binding from the guardian compound and better affinity binding from the O-demethylated metabolite M1 to μ-opioid receptors. In animal styles, M1 is as much as 6 moments more strong than tramadol in generating analgesia and 200 moments more potent in μ-opioid binding. https://haimp206tua1.mdkblog.com/profile