Contraindicated (one)pentobarbital will decrease the level or influence of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the development and elimination of cariprazine's active metabolites. pentobarbital will lower the extent or effect of ibuprofen by influencing hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unf... https://leonardov419uhv0.smblogsites.com/profile