There is a launch of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to reduce afferent suffering transmission and generate analgesia. Hence, medication like clonidine that focus on alpha-2 receptors can affect the transmission of soreness. Relates to clonidine: oral tablet, oral https://www.proleviate.com/post/the-new-pain-killer-conolidine