Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. In contrast to opioids, which bind to µ-opioid receptors inside the central nervous technique, conolidine modulates alternate molecular targets. A Science Developments study found that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://garrettgezxw.blogocial.com/the-best-side-of-alternative-natural-pain-relief-to-replace-traditional-painkillers-74134313